Phellinus linteus (Hymenocaetaceae) has been used for the treatment of gastric cancer noninsulin dependant diabetes, diarrhea, and menstrual irregularity. The antioxidative erect of cultivated fruit body of Phellinus linteus on low den-sity lipoprotein oxidation was investigated. The MeOH and water extracts were examined by TBARS assay on human plasma LDL in vitro system. The MeOH ex. Showed antioxidative activityl and then was fractionated into Precipitates, Water Insoluble fr., Water fr, and ether fr. The results showed that the lipophilic fractions, Water Insoluble fr. And Ether fr. Of cu l-tivated fruit body of Phellinus linteus, inhibited the oxidative modification of LDL.