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Dual Action 기능을 가지도록 설계한 항경련성 전구약물의 합성과 항경련 활성

Design and Synthesis of Anticonvulsive Agents as Potential Dual Acting Prodrugs and Their Anticonvulsive Activities

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This study aimed to synthesize new anticonvulsive agents as potential dual acting prodrugs. For the synthesis of ester or amide prodrug types, p- hydroxybenzaldehyde or valproic acid was coupled with clinically usable anticonvulsants or GABAmimetics with use of DCC/DMAP coupling methods. Also their anticonvulsive activities were evaluated.

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