큰눈물버섯(Psathyrella veluyina) 균사배양물로부터 분리한 단백다당체 PVMP의 면역활성

Immunoactivities of PVMP a Protein-polysaccharide Fraction Isolated from Mycelial Culture of Psathyrella veluyina

ln the previous report, we described the marked antitumor and immunomodulatory activities of PVP, a protein-polysaccharide fraction of a Korean wild mushroom Psathyrella veluyina. In this study, a protein-polysaccharide fraction, PVMP was prepared from the shake-cultured mycelia of the same mushroom and its immunoactivities as well as chemical compositions were investigated. At 200μg/ml, PVMP weakly stimulated the BALB/c mouse splenic Iymphocytes to form Iymphoblasts and upregulated the expression of CD25 molecules, but failed to stimulate peritoneal macrophages. In chemical analysis these two protein-polysaccharide fractions were found to be quite different in that the carbohydrate contents of PVMP and PVP, respectively was 85.3% and 4l.2%. These results reveals that PVMP, unlike PVP, is a moderate immunostimulator on the immune system.