치오우에이도 MAPP 유도체의 합성과 세포독성

Synthesis and Cytotoxicity of Thioureido MAPP Derivatives

The 2-amino-1-phenylpropanols 4-7 were reacted with isothiocyanates to afford the 20 thioureido MAPP derivatives 8a~lle, which were tested their cytotoxic activity by MTT assay, The cytotoxicity of alkylthioureido compounds were increased and decreased by alkyl chain length from C8 to Cl4 and of phenylthioureido compounds showed poor activity. The compounds (8b,8c,9b,9c,1Ob,1Oc,11b,1lc) with C10 and C12 alkyl chains gave stronger activity than reference compound Bl3. The IC50 Of compound 8c was 1.05μM and 3 times stronger activity than Bl3. The stereochemistry of synthesized compounds affected very little to cytotoxic activity.