학술저널
6-트리아졸 엑소메칠렌펜남 유도체의 합성
Synthesis of 6-Triazole Exomethylenepenams Derivatives
- 대한약학회
- 약학회지
- 제48권 제5호 (2004년)
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2004.10303 - 308 (6 pages)
- 2
The synthesis of new 6-triazole exomethylenepenams was described. The 6,6- dibromopenam 5 was reacted with CH3MgBr and substituted triazole 4 to afford the 6-bromo penicillanate 6, which was treated with acetic anhydride to give acetoxy compound 7. The deacetobromination of acetoxy compound 7 with zinc and acetic acid gave 6-exomethylene penams 8 and 9, which were oxidized to sulfones 10 and 11 by m-CPBA. The p-methoxybenzyl compounds 6~11 were deprotected by AlCl3 and neutralized to give the sodium salts 12~17.
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