조혈세포의 분화과정에서 발현되는 유전자의 3' UTR 염기서열의 변화가 유전자 기능의 조절에 미치는 영향에 대한 연구

Frequent Changes of 3' UTR Sequences in the Genes Expressed During Hematopoietic Differentiation Implicates the Importance of 3' UTR in Regulation of Gene Function

The 3' UTR(3' untranslated region) plays important roles in controlling gene expression through regulating 3' polyadenylation, mRNA export, subcellular localization, translational efficiency, and mRNA stability. Changes in the 3' UTR sequence in an expressed transcript can result in functional changes of the genes that are expressed in pathological conditions compared with those genes expressed in normal physiologic conditions. A genome-wide survey of 3' UTR variation was performed for the genes expressed during hematopoietic differentiation from CD34+ stem/progenitor cells to CD15+ myeloid progenitor cells. Wide-spread differential usage of the 3' UTR was observed from the genes expressed during this celluar transition. This study implies that the 3' UTR can be a highly coordinated region for post-transcriptional regulation of the function of expressed genes.