학술저널
만병초의 세포독성 성분
Cytotoxic Constituents of Rhododendron brachycarpum
- 대한약학회
- 약학회지
- 제49권 제3호 (2005년)
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2005.06244 - 248 (5 pages)
- 18
From the methanol extract of Rhododendron brachycarpum four triterpenes, three phenylpropanes and a diterpene alkaloid were isolated. Their structures were identified as glutinol (1), 3β-hydroxyurs-12-ene (2), β-sitosterol (3), (E)-p-hydroxycinnamic acid hexadecylester (4), (-)-rhododendrol (5), (+)-rhododendrol (6), 3β-hydroxyurs-12-en-28-oic acid (7) and gray-anotoxin I (8) by spectroscopic methods. Compound 8 showed moderate cytotoxicity against five cultured human tumor cell lines with ED50 values of 3.21~4.05 μg/ml. The other compounds were of marginal activity against the tested cell lines.
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