노니(Morinda citrifolia) 메타놀 추출물의 Phospholipase A2 억제와 항염증 활성

Anti-inflammatory Activity and Phospholipase A2 Inhibition of Noni (Morinda citrifolia) Methanol Extracts

To investigate anti-inflammatory activity of Noni extracts, we measured the phospholipase A2 activity using both in vitro and in vivo system. Water soluble fraction of Noni extracts did not affect melittin-induced arachidonic acid release, whereas lipid soluble fraction inhibited it in a dose dependent manner in Raw 264.7 cells. The purified phospholipase A2 activity was dese-dependently inhibited by lipid soluble fraction of Noni extracts but not by its water soluble fraction. Lipid peroxidation, myeloperoxidase and phospholipase A2 activity in incised skin of mice were significantly increased as compared with those in non-incised skin, and these increase was attenuated by the treatment with Noni powder. Our data suggest that Noni extracts has anti-inflammatory activity, and this is, in part, caused by inhibitory activity of phospholipase A2.