Elevated Plus-maze를 이용한 Phenylpropanoid의 항불안 효과

Anxiolytic-like Effects of Phenylpropanoids Using the Elevated Plus-Maze in Mice

The purpose of this study was to characterize the putative anxiolytic-like effects of phenylpropanoids using the elevated plus maze (EPM) test in mice. Cinnamic acid, p-coumaric acid, caffeic acid and ferulic acid were orally administered to male ICR mice, 1 h before behavioral evaluation in an EPM, respectively. Control mice were treated with an equal volume of vehicle, and positive control mice diazepam(1 mg/kg). A single treatment with phenylpropanoids (at 8 mg/kg) significantly increased time-spent and arm entries into the open arms of the EPM., and decreased time-spent and arm entries into the closed arms of the EPM versus control (P〈 0.05). However, no changes in the locomotor activity and myorelaxant effect were seen in any group versus the saline control. These results suggest that phenylpropanoids may be an effective anxiolytic agent.