3-Allylthio-6-heterocyclylalkylaminopyridazine 유도체 합성 및 SK-Hep-1 인간간암세포에 대한 항암효과

Synthesis of 3-Allylthio-6-heterocyclylalkylaminopyridazine Derivatives and their Anti-tumor Activities Against SK-Hep-1 Human Liver Cancer Cells

Allylthio group of allicin and other organosulfur compounds which are isolated from garlic is considered as a pharmacophore, a key structure component of the molecule which is responsible biological activities. In the foregoing studies various 3-allylthio-6-alkoxypyridazine derivatives (K-compounds) and 3-allylthio-6-alkylthiopyridazine derivatives(Thio-K-compounds) were synthesized and their biological activities were tested in vivo. They showed good hepatoprotective activities on the carbon tetrachloride-treated mouse and aflatoxin B1-treated rat and chemopreventive activities on hepatocarcinoma cells in rat as expected. Now 3-allylthio-6-alkoxypyridazine is replaced by nitrogen (N) were synthesized and their activities were tested in vitro against SK-Hep-1 human liver cancer cells. They showed good chemopreventive activities on hepatocarcinoma cells.