Phenylephrine에 의한 수축에 대한 Sodium Nitroprusside의 혈관수축 증대효과

The Potentiation Effect of Sodium Nitroprusside on the Contraction Induced by Phenylephrine in Rat Aortic Rings

Rat aortic ring preparations were mounted in organ baths, exposed to sodium cyanide (0.01~1.0mM) for 10min, and then subjected to contractile agents or relaxants such as acetylcholine, sodium nitroprusside and isoproterenol. Presence of low concentration of sodium cyanide did not affect the contractile response to KCl or phenylephrine in the aortic rings with intact endothelium or endothelium denuded. Sodium nitroprusside but not acetylcholine or isoproterenol augmented phenylephrine-induced intact or denuded vascular contraction in the presence of low concentration of sodium cyanide. In conclusion, this study provides the evidence concerning the potentiating effect of sodium nitroprusside on the contraction induced by phenylephrine in rat aortic rings regardless of endothelial function.