학술저널
3치환 7-할로세팔로스폴린 유도체의 합성
Synthesis of 3-substituted 7-Halocephalosporanate Derivatives
- 대한약학회
- 약학회지
- 제50권 제6호 (2006년)
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2006.12393 - 397 (5 pages)
- 5
The synthesis of new 3-substituted 7-halocephalosporanates was described. 7-ACA was reacted with thiols at pH 6.5~6.8 to affored the 3-substituted 7-ACA (1), which was treated with diphenyldiazomethane to give diphenylmethyl 7-aminocephalosporanate (2). The Halogenation of 7-aminocephalosporanate (2) with NaNO2, KBr, and H2SO4gave 7-bro-mocephalosporanate (3) and with NaNO2, HCl gave 7-chlorocephalosporanate (4). Diphenylmethyl cephalosporanate (2~4)were deprotected by AlCl3 in anisole and neutralized to give the sodium cephalosporanate (5~7).
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