학술저널
2-치환 플라본 유도체의 합성
Synthesis of 2-Substiruted Flavone Derivatives
- 대한약학회
- 약학회지
- 제50권 제6호 (2006년)
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2006.12398 - 402 (5 pages)
- 4
Flavone was found to inhibit tyrosinase and reduce synthesis of melanin to show skin-lightening effect. With the hope of identifying-lightening flavones, we synthesized flavone analogs. Substituted benzoic acids (1) were treated with oxalyl chloride in DMF to yield benzoyl chlorides (2), which were reacted with 2-hydroxyacetophenones (3) to afford 2-benzoyloxyacetophenones (4). These acetophenones (4) were converted into 1,3-diketones (5) with base and then treated with acid to give flavone derivatives (6).
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