ICR 생쥐에서 엉겅퀴 잎 추출물의 항우울 효과

The Antidepressant Effects of Cirsium japomicum in ICR Mice

The antidepressant effects of Cirsium japonicum compositae was investigated using open field test and forced swimming test. Total extract of Cirsium japonicum (CJ) was orally administered at dose of 20, 100, 300, 500mg/kg body weight. Supplementation of CJ increase dose-dependently movement, rearing frequency and total turn angle in the center area of open field in mice. Treatment of Cirsium japonicum's extract (360mg/kg, CJ) decreased immobile duration and increased mobile and strong mobile duration significantly, and it is comparable to that of imipramine and fluoxetine. These results indicate that CJ has antidepressant effect. Treatment of CJ did not induced any impairment in motor coordination and myorelaxation. These results indicate that the constituents or its complex of Cirsium japonicum could be a candidate of new antidepressant drug.