Zipeprol 내용액제의 고미교정에 관한 연구

The Mitigation of Bitterness of Zipeprol Solution

Zipeprol, anti-tussive, is considerably bitter. Therefore, it is necessary to mitigate the bitterness in zipeprol syrup for children. In this experiment, it was attempted to mitigate the bitterness of zipeprol by means of polymers such as beta-cyclodextrin, arabic gum, HPMC(hydroxypropyl methylcellulose), PEG 2000(polyethyleneglycol 2000), PVP(polyvinylpyrrolidone). Caffeine was used as the reference standard of bitterness. In the result of this experiment, beta-cyclodextrin would mitigate the bitterness of zipeprol more largely than any other polymers. Arabic gum was the second choice which would mitigate the bitterness of zipeprol.