학술저널
Daidzein의 항염작용과 그 작용기전에 관한 연구(I)
Studies on the anti-inflammatory activity and its mechanism of daidzein
- 대한약학회
- 약학회지
- 제31권 제3호 (1987년)
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1987.06154 - 163 (10 pages)
- 2
Daidzein and its methyl derivatives were synthesized and their anti-inflammatory activities were examined. Daidzein suppressed the carrageenin-induced edema, but its methyl derivatives showed decrease or abolition of the anti-inflammatory effect. Daidzein did not significantly suppress the complete Freund''s adjuvant-induced arthritis, and the mixed phlogistics (histamine + serotonin)-induced edema. Daidzein inhibited the leukocyte emigration and protein exudation when it was administered into the CMC pouch at low doses (5.25mg/pouch). Daidzein significantly suppressed the cotton-pellet granuloma formation.
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