Simple Coacervation에 의한 Beads 및 Sulfamethoxydiazine의 Albumin Microcapsule의 조제에 관한 연구

Preparation of Albumin Microcapsule Containing Beads and Sulfamethoxydiazine by Simple Coacervation

Simple coacervation of bovine serum albumin was studied to prepare biodegradable microcapsule. Albumin microcapsules were prepared by using acrylonitrilestyrene polymer (M-80) resin beads and sulfamethoxydiazine as the core materials. The albumin to beads ratio was found to be 1:2.3 and the albumin to sulfamethoxydiazine ratio to be 1:2.9. The 50% release times (T50%) of sulfamethoxydiazine and microencapsulated sulfamethoxydiazine were 6 min. and 73 min., respectively. The surface appearance of the microcapsule collected after release experiment was not different from those of the original microcapsule. In addition to slowing release of drug the microencapsulation process masked characteristic bitter taste of sulfamethoxydiazine.