유기산성약물이 푸로세미드의 흡수, 배설 및 이뇨효과에 미치는 영향

The Effects of Organic Acidic Drugs on the Absorption, Excretion and Diuretic Action of Furosemide

The effects of organic acidic drugs on the absorption, excretion and diuretic action of furosemide were studied. Cefalexin, p-aminohippuric acid (PAH), ibuprofen and p-aminosalicylic acid (PAS) were selected as organic acidic drugs. The in situ absorption rate and absorption rate constant of furosemide (30mcM) were significantly (p<0.05) decreased by 3OmcM of cefalexin, PAH, ibuprofen and PAS in rat small intestine. The plasma concentration of furosemide was significantly (p<0.01) increased by cefalexin, PAH and ibuprofen in rabbits. But the urinary excretion rate, renal clearance and diuretic action of furosemide were significantly (p<0.05) decreased by cefalexin, PAH, ibuprofen and PAS in rabbits.