학술저널
2(2'',2''-디에톡시에틸)아미노벤즈아마이드의 고리화반응(I)
Cyclization Reaction of 2(2'',2''-Diethoxyethyl)Aminobenzamide
- 대한약학회
- 약학회지
- 제31권 제6호 (1987년)
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1987.12370 - 375 (6 pages)
- 2
1,4-Benzodiazepin 5-one was prepared from 2-aminobenzamide derivatives by acid catalyzed intermolecular cyclization. N-Alkylation of 2-aminobenzamide with alpha-bromo acetaldehyde diethylacetal to 2(2'',2''-diethoxyethyl)aminobenzamide (I) and subsequent treatment of I with acid gave 1,4-benzdiazepin 5-one, where as the acetyl derivatives of I did not react to 1,4-benzodiazepin 5-one but to methyl 4-quinazolone (IV).
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