Piperine이 적출 백서 정관내의 교감신경계에 미치는 영향

Effect of Piperine on Peripheral Sympathetic Nervous System in Isolated Vas deferens of Rat

To elucidate one of the effect of piperine on the peripheral sympathetic nervous system, influence of piperine upon the contractile action of norepinephrine, methoxamine and tyramine as well as uptake and release of [3H]-norepinephrine has been investigated in naive and chronic piperine-treated vas deferens of rats. pA2 value for alpha1-adrenoceptor of phentolamine was significantly increased. Chronic piperine-treated group was markedly shown increased efflux of [3H]-norepinephrine and muscular tension, but was not affected the neuronal up-take and release of [3H]-norepinephrine. It can be concluded that potentiation of the effect of norepinephrine by acute and chronic piperine treated group may be due to the change of affinity of alpha1-adrenoceptor, and partly due to possible modification of storage mechanism.