학술저널
가스 크로마토그래피에 의한 아민노산 광학 이성질체의 분리(III) (S)-5-isobutyl-N3-phenyl-2-thiohydantoin의 광학 활성 고정상으로의 응용
Separation of Amino Acid Enantiomers by Gas Chromatography(III) (S)-5-isobutyl-N3-phenyl-2-thiohydantoin as chiral stationary phase
- 대한약학회
- 약학회지
- 제32권 제2호 (1988년)
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1988.04112 - 116 (5 pages)
- 23
The resolution of N-trifluoroacetyl(N-TFA) ter-isopropylesters of Ala, Ile, Leu, Val and Phe by gas chromatography on the (S)-5-isobutyl-N3-phenyl-2-thiohydantoin as stationary phase was investigated. The phase was employed at several column temperatures(140oC-200oC) and the separation factors were 1.18-1.45 range for five amino acid enantiomers. The possible mechanism of chiral recognition was investigated by NMR technique and the association constant(Kc) was calculated as 201.3(r=0.98) for alanyl derivative.
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