학술저널
Doxorubicin유발 심장독성에 미치는 L-Carnitine의 효과
Effect of L-Carnitine on the Cardioxicity Induced by Doxorubicin
- 대한약학회
- 약학회지
- 제32권 제4호 (1988년)
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1988.08230 - 233 (4 pages)
- 5
This study was undertaken to elucidate the role of L-carnitine on cardiotoxicity induced by doxorubicin in mice. We designed to investigate both lipoperoxidation and histopathology in experimental group. The results obtained from prior with concurrent treatment of L-carnitine showed as follows; 1) Combination of L-carnitine showed significant inhibition of lipoperoxide in liver than heart. 2) By means of electron microscopy, we obtained histological evidence that doxorubicin-induced cardiomyopathy, is prevented by L-carnitine.
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