학술저널
New synthetic method for ibuprofen, which is a potent antiinflammatory agent, was described. Ethyl alpha-methylthio-p-isobutylphenylacetate was obtained from Friedel-Crafts reaction of isobutylbenzene with ethyl alpha-chloro-alpha-(methylthio)acetate in the presence of SnCl4. Ibuprofen was prepared in good yield by treatment of ethyl alpha-methylthio-p-isobutylphenylacetate with NaH and MeI, followed by desulfurization with zinc dust-acetic acid and hydrolysis of the resultant ethyl 2-methylthio-2-(4-isobutylphenyl)propionate.
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