학술저널
Glucose를 비타민 C로 변형시키는 과정의 최적화에 대한 연구
Optimization of the Transformation of D-Glucose to Vitamin C
- 대한약학회
- 약학회지
- 제32권 제6호 (1988년)
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1988.12386 - 393 (8 pages)
- 5
Chemical transformation of D-glucose to 2-keto-L-gulonic acid and L-ascorbic acid has been examined. D-Sorbitol obtained from D-glucose was microbiologically oxidized to L-sorbose by G. suboxydans in 90% yield. On treatment of L-sorbose with acetone in the presence of sulfuric acid, its diacetonide is obtained in 95% yield. This diacetonide is oxidized to the corresponding acid with nickel chloride-hypochlorite, and the acid is directly transformed to L-ascorbic acid. The over all yield of Vitamin C from D-glucose achieved is 54%.
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