학술저널
항 결핵제, 리팜피신에 내성인 유산균의 개발
Development of Lactobacillus casei Resistant to Rifampicin, an Antituberculosis Agent
- 대한약학회
- 약학회지
- 제32권 제6호 (1988년)
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1988.12394 - 401 (8 pages)
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Lactobacillus casei was treated with N-methyl-N''-nitro-N-nitrosoguanidine(NTG) to obtain resistant mutants to rifampicin. Freshly grown cells of the strain suspended in tris-maleic acid buffer were exposed to NTG of 50mcg/ml for 30 min. Five colonies of the NTG-induced mutants showed distinct resistance to rifampicin. They also exhibited identical characteristics with the original Lactobacillus casei when they were tested for growth, titrable acidity and sugar fermentation. It is suggested that they can be utilized as efficient starter cultures for fermented milk.
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