마우스에 있어서 에이코사펜타엔산이 면역반응에 미치는 영향(II) II. 세포성 면역 및 비특이적 면역

The Effect of Eicosapentaenoic. Acid on the Immune Response in Mice(II) II. Cell-mediated immunity and Nonspecific Immunity

The cellular and nonspecific immune response of EPA were investigated in mice. ICR male mice were divided into 8 groups and received intraperiteneal injection of EPA(5mg, 10mg, 20mg/kg) for 4 weeks. Cyclophosphamide(5mg/kg) was administered i.p. 2 days prior to secondary immunization. Immune responses were evaluated by hypersensitivity to SRBC(DTH), rosette forming cell(RFC), natural killer(NK) cell activity and macrophage activity. The obtained results were as follows: As compared to normal group, 1) DTH was increased by EPA 5mg, 10mg administration groups. 2) RFC was significantly increased by EPA 20mg administration group. 3) NK-Cell activity was significantly increased by EPA 10mg administration group. 4) Macrophage activity was enhanced by EPA 5mg administration group.