학술저널
인삼중의 세포독성물질 10-Acetyl panaxytriol의 분리
10-Acetyl panaxytriol, A new cytotoxic polyacetylene from Panax ginseng
- 대한약학회
- 약학회지
- 제33권 제2호 (1989년)
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1989.04118 - 123 (6 pages)
- 3
A new polyacetylene compound which has strong cytotoxic activity against L1210 cell, was isolated from Korean ginseng roots. The structure was determined to be heptadeca-1-ene-4,6-diyne-3,9-diol-10-acetate (10-acetyl panaxytriol, ED50=1.2mcg/ml). The cytotoxicities of this compound and acetyl panaxydol lower than their starting substances, panaxytriol and panaxydol. The presence of one acetyl group in the polyacetylenes was responsible for the decreases in the cytotoxicities.
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