학술저널
약물-고분자물질 결합체 합성연구 : 5-fluorouracil과 사람의 혈청 Albumin 및 Poly-L-lysine 결합체 합성
Synthesis of Drug-macromolecule Conjugates: Conjugations of 5-Fluorouracil to Human Serum Albumin and Poly-L-lysine
- 대한약학회
- 약학회지
- 제33권 제5호 (1989년)
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1989.10267 - 272 (6 pages)
- 5
The drug-macromolecule conjugates i.e. 5-fluorouracil-1-acetyl-human serum albumin(FU-AA-HSA, 8) and 5-fluorouracil-1-acetyl-poly-L-lysine(FU-AA-polylys, 9) have been synthesized and purified by sephadex G-25 gel filtration with 0.05M phosphate buffer(pH 7.5). The analyses of conjugates gave the molar ratio of FU-AA : HSA of 70-100:1 and FU-AA: poly-L-lysine of 109:1. The weight percent of FU-AA(as FU-CH2CO-) in FU-AA-HSA conjugate was 16-22% and the one in FU-AA-polylys was 22.4%.
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