푸로세미드와 안지오텐신 차단제와 상호작용

Interaction of Furosemide and Angiotensin Inhibitor

This paper was attempted to investigate effect of angiotensin inhibitor (loading dose 25, 50, 100mcg/kg and maintenance dose 12.5, 25, 50mcg/kg/hr) on the pharmacokinetics of furosemide (5mg/kg i.v) in rabbit. The plasma concentrations of furosemide increased by angiotensin inhibitor and the relative bioavailability of furosemide increased from 118.1% to 193.2% by the inhibitor. The protein binding of furosemide decreased by angiotensin inhibitor in bovine serum albumin (2.17 X 10-4M) by equilibrium dialysis method. Consequently, dosage regimen of furosemide might be adjusted carefully when furosemide is administered with angiotensin inhibitor.