Bis(2,4-diaminophenyl)phosphonate-KIO3에 의한 환원성 약품(Ascorbic Acid, Potassium Antimonyl Tartrate, Isonicotinic Acid Hydrazide)의 분광광도정량

Spectrophotometric Determination of Reducing Drugs (Ascorbic Acid, Potassium Antimonyl Tartrate, Isonicotinic Acid Hydrazide) with Bis(2,4-diaminophenyl)phosphonate-KI03

Aqueous solution of bis(2,4-diaminophenyl)phosphonate(APP) was very stabler especially below pH 2.0 and the red-color compound formed by the reaction of APP and I03- was stable at room temperature. A simple and rapid spectrophotometric method for the determination of ascorbic acid, potassium antimonyl tartrate(PAT), and isonicotinic acid hydrazide(INAH) was established by the reaction of I03- and these reducing drugs, and the absorbance measurements were made at 500nm. In the reaction of I03- and each of the reducing drugs, the conditions of pH were suitable below 2.5 for ascorbic acid, below 2.0 for PAT, and below 1.5 for INAH. Beer''s law did hold in the range of 17.6-1549.9mcg for ascorbic acid, 33.4-2871.8mcg for PAT, and 6.9 -548.6mcg for INAH. Many common ingredients present in pharmaceutical dosage forms did not interfere. The average recoveries for ascorbic acid and INAH in pharmaceutical formulations were 99.8-100.3 +/- 0.2-0.4%, 99.8 +/- 0.3%, respectively.