학술저널
가토에서의 Praziquantel의 체내 동태
Pharmacokinetics of Praziquantel in Rabbits
- 대한약학회
- 약학회지
- 제34권 제1호 (1990년)
-
1990.0240 - 46 (7 pages)
- 2
Pharmacokinetic studies on praziquantel in rabbits were performed in this paper. The pharmacologically active parent drug was separated from the pharmacologically inactive metabolites by HPLC method. The pharmacokinetic parameters of parent drug were obtained. In vitro partition to blood cells of praziquantel was measured. The mean value (n = 3) of partition to blood cells was 44% at concentrations between 1mcg/ml and 40mcg/ml. Therefore, the relatively high partition to blood cells should be considered in further pharmacokinetic studies on praziquantel.
(0)
(0)