학술저널
7 beta-Diphenyl Triazolyl Thioacetamidocephalosporin의 합성과 항균작용
Synthesis and Antimicrobial Activity of 7 beta-Diphenyl Triazolyl Thioacetamido Cephalosporin
- 대한약학회
- 약학회지
- 제34권 제2호 (1990년)
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1990.04117 - 121 (5 pages)
- 3
7beta-[4-Phenyl-5-(3.4.5-trimethoxyphenyl)-4H-1.2.4-triazol-3-yl]thioacetoamidocepharosporanic acid was synthesized by condensation of 7-Aminocephalosporanic acid (7-ACA) with [4-Phenyl-5-(3.4.5-trimethoxyphenyl)-4H-1.2.4-triazol-3-yl] thioacetylchloride. This compound was tested for antimicrobial activity in vitro against nine species of microorganisms. It showed remarkable antibacterial activity against Bacillus subtilis, Micrococcus luteus, and Staphylococcus aureus.
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