충치균에 대한 생리활성 생약성분의 분리 및 약효평가(2) 호장근의 항균성분과 안정성에 대하여
The Isolation and Evaluation of Bioactive Components from Crude Drugs Against a Cariogenic Bacterium, Streptococcus mutans OMZ 176(2) An Antibacterial Component of Polygoni Radix and Its Safety
- 대한약학회
- 약학회지
- 제34권 제4호 (1990년)
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1990.08277 - 281 (5 pages)
- 14
The isolation and identification of an antibacterial component, from Polygoni Radix against a cariogenic bacterium Streptococcus mutans OMZ 176, were carried out for development of anticariogenic agents. The bioactive component was identified to be emodin. The minimal inhibitory concentration (MIC) of emodin was 100mcg/ml against S. mutans OMZ 176. The bioactive component emodin weakly inhibited beta-lactamase activity with the inhibition ratio of 1.7, 4.3 and 7.6% at the concentration of 50, 100, and 200mcM, respectively. Emodin exhibited slight phototoxicity when analysed by the photohemolysis method.
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