Protoberberine 유도체합성 및 활성연구

Synthesis of Protoberberine Derivatives and Studies on Their Biological Activities

Irradiation of the berberinephenolbetaine in a stream of argon produced the 8,14-cycloberberines[1]. On treatment with ethylchloroformate C8-N bond cleavage of the compound[1] occurred, accompanied with dehydrochlorination to give 7-ethylcarboxyisoquinoline[3], and the product[3] treated with strong alkali solution to give the 13-oxonorotensane[4] in 64% yield. Irradiation of the compound[4] converted easily to dihydro-8H-dibenzo[a, g] quinolizine-8-one[5]. and then the compound[5] was treated with methyliodide to give the 8-oxo-quinolizinium methiode. The intermediate colume chromatography on IRA-400 afforded the benzo[c, g]azecine-5-one[6] in 63% yield. The result of biological activities for these compounds are also presented.