Flavonoids의 약리작용(II) -항염작용과 창상치유 억제작용과의 상관성-

Pharmacological Activities of Flavonoids(II) Relationships of Anti-inflammatory and Antigranulomatous Actions

The relationships of inhibitory activities of inflammation and wound healing of flavonoids were studied in vitro and in vivo. Generally flavonoids have not only significantly anti-inflammatory activity in carrageenin-induced paw edema and Freund''s complete adjuvant-induced arthritis, but also inhibitory activity of wound healing. The more inhibitory activities Of wound healing flavonoids have. the more they have the anti-inflammatory activities; apigenin > guercetin > flovone > rutin > hesperidin > naringin. Their inhibitory mechanism seems to be inhibition of the inflammatory cell infiltration and fibroblast proliferation, and so they decreased the granulomatous activity and tensile strength.