항응고성의 3-(N-Arylamino)-1,4-Naphthoquinone 유도체 합성(III)

Synthesis of Anticoagulant 3-(N-Aryalmino)-1,4-Naphthoquinones(III)

2,3-Dibromo-1.4-naphthoquinone was reacted with p-aminobenzoic acid, 2-aminopyridine, 2-amino-4-methylpyridine, m-nitroaniline, sulfathiazol, p-chloroaniline, phenetidine and 2-bromo-3-(N-arylamino)-1,4-naphthoquinones(1 - 8). 2,3-Epoxy-2,3-dihydro-1,4-naphthoquinone was also reacted with p-amonobenzoic acid, p-toluidine, p-chloroaniline, m-chloroaniline, m-nitroaniline, p-phenetidine, N,N-dimethyl-1,4-pheylenediamine as a ring opening and dehydrogenation to form 2-hydroxy-3-(N-arylamino)-naphthoquinones(9 - 16) in good yield. These new compounds(1 - 16) are expected to have a biological activities such as anticoagulant and cytotoxic.