학술저널
Cyclic Peptide, Ro09-0198의 혈소판활성화에 대한 작용기전
Mechanism of Platelet Activation Induced by Cyclic Peptide, Ro09-0198
- 대한약학회
- 약학회지
- 제35권 제1호 (1991년)
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1991.0211 - 14 (4 pages)
- 2
RoO9-0198, a cyclic peptide isolated from culture filtrates of Streptoverticillium griseoverticillatum, induced platelet aggregation and serotonin release simultaneously. LDH release was not observed. Addition of peptide to rat platelet, loaded with Ca2+ chelator quin-2, caused immediate rise in cytosolic free Ca2+. Liposomal membrane containing phosphatidylethanolamine was damaged by peptide and released 45Ca dose dependently.
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