학술저널
분자내 고리화반응에 의한 -4,9-Dione 유도체 합성
Synthesis of -4,9-Dione Derivatives via Intramolecular Cyclization
- 대한약학회
- 약학회지
- 제35권 제3호 (1991년)
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1991.06231 - 235 (5 pages)
- 5
Compounds of the structure of -4,9-dione are known to have an anti-bacterial activity against Gram-positive bacteria. New kinds of 2-amino--4,9-diones are prepared via intramolecular cyclization. 2-Chloro-3-(a-cyano-alpha-ethoxycarbonyl-methyl)-1,4-naphthoquinone was reacted with some alkylamines(methylamine, ethylamine, ethanolamine, isopropylamine, cyclohexylamine, benzylamine) to yield 2-amino-3-ethoxycarbonyl-N-alkyl--4,9-diones.
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