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1-[(2-Phenyl-1,3-benzodioxol-2-yl)methyl]-1H-imidazole 유도체의 합성 및 항진균작용

Synthesis and Antifungal Activities of 1-[(2-Phenyl-1,3-benzodioxol-2-yl)methyl]-1H-imidazole Derivatives

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The synthesis of 1-[(2-phenyl-1,3-benzodioxol-2-yl)methyl]-1H-imidazole derivatives is described starting with 2-bromoacetophenones and catechols. l-[(2-Phenyl-1,3-benzodioxol-2-yl)methyl]-1H-imidazole (9-12) showed potent broad-spectrum activity, not only against Candida species but also Cr. neoformans, S. cerevisiae and T. mentagrophytes.

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