Thiocarbamyl Enoxacin 유도체의 합성 및 항균작용

Synthesis and Antimicrobial Activities of Thiocarbamyl Enoxacin Derivatives

Treatment of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid (Enoxacin) with alkyl(or aryl) isothiocyanates which obtained from alkyl(or aryl) amines afforded six 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-alkylthiocarbamylpiperazinyl)-1,8-naphthyridine-3-carboxylic acids and five 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-arylthiocarbamyl piperazinyl)-1,8-naphthyridine-3-carboxylic acids. The compounds synthesized were evaluated for their antimicrobial activities, in vitro, against Eschelichia coli 6-PE-4, Bacillus subtilis 74-51, Proteus vulgaris 78645, Klebsiella pneumoniae JYA-78314, Staphylococcus aureus 79110 and Pseudomonas aeruginosa 8765-1 P2.