관류 흰쥐 간에서 1,2-Dioctanoyl-sn-Glycerol에 의한 글루코오스의 유리작용

Glucose Release Induced by 1,2-Dioctanoyl-sn-Glycerol in Perfused Rat Liver

The effect of diacylglycerol on glucose release was studied by using 1,2-dioctanoyl- sn-glycerol (diC8), a cell permeable diacylglycerol, in perfused rat liver. The glucose release was increased by diC8(50 mcM), and the effect was depended on calcium ions. The increment of glucose release by diC8(50 mcM) was inhibited by indomethacin (50 mcM); the amount of glucose release was almost the same with that of control group. Arachidonic acid(200 mcM) also increased glucose release and the release was inhibited by indomethacin. There was no synergistic effect on glucose release by the combination of diC8(50 mcM) and phenylephrine(10 mcM).