학술저널
3-메칠-2,3-디히드로 벤즈(f)인돌-2,4,9-트리온 유도체의 합성
Synthesis of 3-Methyl-2,3-dihydrobenz(f)indole-2,4,9-trione Derivatives
- 대한약학회
- 약학회지
- 제40권 제3호 (1996년)
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1996.06273 - 278 (6 pages)
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The 2,3-dichloro-1,4-naphthoquinone was reacted with diethyl methylmalonate and sodium amide in the toluene to yield 3-chloro-2-(1-methyl-1-diethoxycarbonyl)-methyl-1,4-naphthoquinone(I). When this compound I was reacted with some alkylamines (methylamine, ethylamine, ethanolamine, 2-bromoethylamine, propylamine, isopropylamine, cyclohexylamine, benzylamine, 4-piperidylmethylamine), 3-methyl-2,3-dihydrobenz(f)indole-2,4,9-trione derivatives(IIa-i) were obtained via intramolecular cyclization.
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