사염화탄소에 의해 유발된 간독성에 대한 galangin의 보호효과

Protective Effects of Galangin on Carbon tetrachloride-Induced Hepatotoxicity

In order to evaluate the protective effects of galangin on CCl4-induced hepatotoxicity, GOT, GPT and malondialdehyde(MDA) values were measured in ICR mice. Galangin,a flavonoid compound, was administered orally for six days and immediately CCl4 was injected intraperitoneally after the last dose of galangin. Mice were sacrificed at 24h after the administration of CCl4. In the multiple pre-treatments for 6 consecutive days, galangin showed more potent protective effects than silymarin as reference active compound in serum GOT, GPT and MDA values in the liver at all doses tested. Antioxidative activity was determined by measuring the amounts of MDA formed from ethyl linoleate by H2O2 in vitro. Galangin showed higher inhibition than silymarin. These results demonstrate a possible hepato-protective role of galangin against CCl4-induced hepatotoxicity in vivo and H2O2-induced lipid peroxidation in vitro. Therefore, galangin may be capable of protecting hepatotoxicity.