학술저널
새로운 알릴아민 항진균제의 합성과 생물학적 평가
Synthesis and Biological Evaluation of New Allylamine Antimycotics
- 대한약학회
- 약학회지
- 제40권 제5호 (1996년)
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1996.10507 - 512 (6 pages)
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Some allylamine compounds which are benzothiazole substituants in stead of naphthyl ring in naftifine, antifungal agents, were synthesized as potential antimycotics. The intermediate Schiff bases that were obtained by condensation of 2-aminobenzothiazole and trans-cinnamaldehyde, were reduced to imine compounds to give allylamines (5a-5d) after methylation. These compounds which were tested in vitro against five fungal cell lines containing Trichophyton mentagrophytes, showed no activity in 0.1~100mcg/ml range.
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