학술저널
(-)-4-(파라클로로비페닐)-2-히드록시테트론 산의 합성
Synthesis of (-)-4-(p-Chlorobiphenyl)-2-hydroxytetronic Acid
- 대한약학회
- 약학회지
- 제40권 제5호 (1996년)
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1996.10539 - 544 (6 pages)
- 2
4-Aryl-2-hydroxytetronic acids which can be construded as a "lipophilic vitamin C analogue", are known to have antilipidemic and antiaggregatory activities in stead of antiscorbutic activity of vitamin C. A new compound 4-(p-chlorobiphenyl)-2-hydroxytetronic acid (8), which is structurally closely connected with the most active 4-(p-chlorophenyl)-2-hydroxytetronic acid, was synthesized from alpha-(p-chlorobiphenyl)-alpha-hydroxyacetic acid (1) through 7 steps as a potentially bioactive compound.
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