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Flavonoids from the Leaves of Rubus Coreanum

Rubus coreantim (Rosaceae), which has been used in oriental traditional medicine as the remedies for impotence, pollution and premature ejaculation, bet-wetting and frequency of urination. is a fruit drug cultivating throughout southern Korea. The leaves of Rubus coreanum were extracted with 80% acetone. The extracts were separated by Ambellite XAD-2, Sephadex LH-20. MCI-gel CHP 20P and Cosmosil 75 C18,, OPN. And three flavonoids were isolated. The structures of these compounds were elucidated as quercetin-3-O-beta-D-glueuronopyranoside(l). quercetin-3-O-beta-D-glueuronopyranosyl methyl ester(2), quercetin-3-O-beta-D-xylopyranosyl-(2 -> 1)-beta-glucopyranoside(3) on the basis of physicochemical and spectroscopic evidences.