학술저널
항암제로서의 (+/-)-3-데옥시제리쿠드라닌 A의 설계 및 합성
Design and Synthesis of (+/-)-3-Deoxygericudranin A as an Antitumour Agent
- 대한약학회
- 약학회지
- 제41권 제1호 (1997년)
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1997.0114 - 17 (4 pages)
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(+/-)-3 Deoxygericudranin A was designed and synthesized for the development of novel antitumour agent and for the elucidation of the effect of 3-hydroxyl group in gericudranin A on antitumour activity. 2,4.6-Trihydroxyacetophenone was converted to 3-deoxygericudranin A in 5 steps via sequential protection, aldol condensation, Michael tvpe-cyclization, regioselective, C-benzylation and deprotection.
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