학술저널
빌로바라이드가 글루타메이트에 의한 신경독성에 미치는 영향
Bilobalide Attenuates Glutamate-Induced Neurotoxicity in Primary Cultures of Rat Cortical Cells
- 대한약학회
- 약학회지
- 제41권 제1호 (1997년)
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1997.01111 - 116 (6 pages)
- 13
The neurotoxicity induced by L-glutamate in primary cultures of rat cortical cells could be attenuated by sesquiterpene constituent of Ginkgo biloba leaves, bilobalide. At the concentration of 100 nM, Bilobalide elevated the combined levels of reduced/oxidized glutathione in rat cortical cells exposed to 100mcM glutamate. Furthermore, bilobalide promoted a reduction in superoxide dismutase activity in glutamate-treated cells. Finally, bilobalide markedly inhibited the production of malondialdehyde. a measure of lipid peroxidation, in glutamate-treated rat cortical cells.
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