학술저널
메틸유제놀에 의한 즉시형 과민 반응의 억제
Suppression of Immediate Hypersensitivity by Methyleugenol
- 대한약학회
- 약학회지
- 제41권 제2호 (1997년)
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1997.04268 - 272 (5 pages)
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We studied the action of methyleugenol on immediate hypersensitivity. Methyleugenol completely inhibited systemic anaphylaxis induced by compound 48/80 in mice. Methyleugenol also inhibited local anaphylaxis induced by anti-dinitrophenyl (DNP) IgE. Moreover, methyleugenol dose-dependently inhibited histamine release in peritoneal mast cells activated by compound 48/80 or anti-DNP IgE. These results suggest that the inhibitory effect of methyleugenol on anaphylaxis induced by compound 48/80 or anti-DNP IgE is due to, in part at least, the membrane stabilization of mast cells.
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