학술저널
항암제 안티네오플라스톤 A10의 동족체합성 및 항암 활성
Synthesis and Antitumor Activity of Antineoplaston A10 Analogs as potential Antineoplastic Agents
- 대한약학회
- 약학회지
- 제41권 제3호 (1997년)
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1997.06283 - 293 (11 pages)
- 22
Some analogs and their Mannich bases of Antineoplaston A10 (A10) were synthesized. Chemical yield for the 2-(or 3-)thienyl, benzol, and phenylpropionyl analogs were high but 1-naphthyl analog was synthesized in low yield. the Mannich bases formation of these analogs with morpholine went verywell compared to other bases. 1-Naphthyl, 4-nitrobenzoyl, and phenylpropionyl analogs of A10 showed weak in vitro activity but the other A10 analogs showed weaker or no activity at 10-1000mcg/ml. But their Mannich bases containing A10analogs showed good in vitro activity compared to simple A10 analogs.
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